Streptozotocin analogs
US3940383A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 12, 1974 |
| Grant date | Feb 24, 1976 |
| Priority date | — |
| Expiry date | Dec 12, 1994 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H13/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
New 3-methyl-3-nitrosoureido derivatives of the following amino sugars were prepared as analogs of streptozotocin with the anomeric carbon protected, by nitrosating the methylureas in water with N.sub.2 O.sub.3 : 3-amino-3-deoxy-1,2-O-isopropylidene-.alpha.-D-ribofuranose; methyl 3-amino-3-deoxy-.beta.-D-xylopyranoside; methyl 3-amino-3-deoxy-.alpha.-D-altropyranoside; methyl 3-amino-3-deoxy-.alpha.-D-glucopyranoside; and methyl 3-amino-2,3,6-trideoxy-.alpha.-L-lyxohexopyranoside. Tests against murine leukemia L1210 show that the anticancer activity of streptozotocin not only was retained but was enhanced in most of these derivatives.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.