New water-insoluble preparations of peptide materials, their production and their use

US3941756A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Fritz Huper · Wuppertal, DE
• Erich Rauenbusch · Wuppertal, DE
• Gunter Schmidt-Kastner
• Bruno Bomer · Bensberg, DE
• Herbert Bartl · Odenthal, DE

Key dates

• Filing date: Jun 20, 1974
• Grant date: Mar 2, 1976
• Expiry date: Jun 20, 1994

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N11/082
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

There are disclosed water-insoluble proteinic preparations in which a protein or polypeptide is bound to a copolymer, which preparations are useful for binding enzymes in order to carry out enzyme-catalyzable reactions. These preparations comprise a peptide material bound to a crosslinked copolymer comprising the following copolymerized units: PA1 A. about 0.1 to 30 wt. % of at least one .alpha.,.beta.-monoolefinically unsaturated dicarboxylic acid anhydride having about 4 to 9 carbon atoms; PA1 B. about 35 to 90 wt. % of at least one di- and/or poly(meth)acrylate of a diol and/or polyol as hereinafter defined; and PA1 C. about 5 to 60 wt. % of at least one hydrophilic monomer, The copolymer having a bulk volume of 1.4 to 30 ml/g and a specific surface area of about 1 to 500 m.sup.2 /g, and containing, after saponification of the anhydride groups, about 0.01 to 14 milliequivalents of acid per gram.