Method for producing 2-(substituted thio)-3-cephem derivatives
US3941779A · kind A · utility
3Cited by
1References
20Claims
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Assignee
Inventors
Key dates
| Filing date | Nov 12, 1973 |
| Grant date | Mar 2, 1976 |
| Priority date | — |
| Expiry date | Nov 12, 1993 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D501/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Treatment of a 7-imido-3-cephem carboxylic acid ester with a thiolating agent in the presence of a strong base yields a 4-(substituted thio)-2-cephem derivative which can be made to rearrange by use of a strong acid to obtain a 2-substituted thio-2-cephem derivative which has antimicrobial activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.