Amino derivatives of 1,4-benzodioxan
US3944549A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Oct 23, 1973 |
| Grant date | Mar 16, 1976 |
| Priority date | — |
| Expiry date | Oct 23, 1993 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P9/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
1-[2-(1,4-benzodioxanyl)methyl]-4-(2-hydroxyethyl)-piperazine hemifumarate and the related compounds of formula: ##SPC1## In which R is hydrogen or alkyl; and A is --Z--OR.sub.1, --CH.sub.2 CHOR".sub.1 CH.sub.2 OR'.sub.1, --Z--CO--B or amidino, where Z is a linear or branched divalent hydrocarbon chain of 1 to 3 carbon atoms, R'.sub.1 and R".sub.1, which may be identical or different, are each hydrogen, alkyl, or acyl, B is OH, alkoxy, or a secondary, tertiary or N-heterocyclic amino radical, and R.sub.1 is alkyl, acyl other than nicotinoyl or 3,4,5-trimethoxy-benzoyl, or, when R is other than hydrogen, hydrogen, and its acid addition salts, are useful in therapy as vasodilators and .alpha.-blocking agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.