N-Coumaranyl and chromanyl -methyl-or sulfur analogs thereof-N'- thiazolyl piperazines

US3944551A · kind A · utility

Assignee

• Science Union et Cie · FR

Inventors

• Gilbert Regnier · Le Plessis-Robinson, FR
• Roger Canevari · Élancourt, FR
• Michel Laubie · Vaucresson, FR
• Jean-Claude Poignantw · Les Ulis, FR

Key dates

• Filing date: Mar 25, 1974
• Grant date: Mar 16, 1976
• Expiry date: Mar 25, 1994

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disubstituted piperazines of the formula: ##SPC1## Wherein: PA0 n is 1 or 2; PA0 X is oxygen or sulfur; PA0 R is hydrogen or lower alkyl; PA0 Het is pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, quinolyl, quinazolyl, thiazolyl or benzothiazolyl, each optionally substituted by one or more lower alkyl, lower alkoxy, phenyl, amino, mono or di-lower-alkylamino, or hydroxy, and, ##SPC2## Is always bonded to the benzene ring. These compounds are used as medicines especially in the treatment of peripheral vascular disorders, Parkinson's disease, hypertension and as antipregnancy drugs.