Manufacture of 2-(alkyl)amino-4-hydroxy-5-alkylpyrimidines
US3947440A · kind A · utility
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Key dates
| Filing date | Jan 2, 1974 |
| Grant date | Mar 30, 1976 |
| Priority date | — |
| Expiry date | Jan 2, 1994 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D239/48
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Reaction of a 2-amino-, 2-alkylamino- or 2-dialkylamino-4-hydroxypyrimidine, preferably also containing a methyl group at the 6 position, with an aldehyde R--CHO in presence of hydrogen and a hydrogenation catalyst introduces an alkyl group R--CH.sub.2 -- into the 5 position. The reaction is preferably carried out under superatmospheric pressure at a temperature between 80.degree. and 180.degree.C and is aided by metal salts, acids, amines, amine salts or basic ion-exchange resins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.