Patent · US Expired

Substituted 2-amino-4-(hydroxyamino)-pyrimidines

US3947441A · kind A · utility

3Cited by
1References
8Claims
0Family size

Assignee

Inventors

Key dates

Filing dateAug 20, 1974
Grant dateMar 30, 1976
Priority date—
Expiry dateAug 20, 1994

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07D239/49
  • WIPO fieldOrganic fine chemistry
  • WIPO sectorChemistry

Abstract

Cpmpounds of the class of 5-substituted and 5,6-disubstituted 2-amino-4-(hydroxyamino) and 2,4-bis-(hydroxyamino)pyrimidines and their pharmaceutically acceptable acid addition salts possess valuable biological properties, in particular antibacterial and antimalarial activity and potentiate the action of antibacterial sulphanilamide derivatives. Specific embodiments are 2-amino-4-(hydroxyamino)-5-(3,4,5-trimethoxybenzyl)-pyrimidine, and 2-amino-4-(hydroxyamino)-5-(p-chlorophenyl)-6-ethyl pyrimidine and its hydrochloride.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.