Alkylated 3,20-diketo-.DELTA..sup.4 -steroids of the pregnane series
US3947478A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 22, 1974 |
| Grant date | Mar 30, 1976 |
| Priority date | — |
| Expiry date | Nov 22, 1994 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J41/0055
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to novel alkylated steroids of the pregnane series having the formula: ##SPC1## , wherein PA1 X = a member of the group consisting of H and halogen; PA1 Y = a member of the group consisting of H.sub.2, H(OH), H(OAcyl) and O; PA1 R.sub.1 = a member of the group consisting of H, CH.sub.3 and halogen; PA1 R.sub.2 = alkyl having 1-4 carbon atoms; PA1 R.sub.3 = a member of the group consisting of H (except when Y = H.sub.2), OAcyl, Oalkyl, and CH.sub.3 ; PA1 R.sub.4 = a member of the group consisting of H and alkyl having 1-4 carbon atoms and in which at least one of the substituents R.sub.3 and R.sub.4 is alkyl; and PA1 C.sub.1 -c.sub.2 and C.sub.6 -C.sub.7 are selected from a saturated and an unsaturated bond. The novel compounds possess strong anti-inflammatory properties and are useful in the treatment of inflammatory conditions especially those associated with the skin and allergic reactions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.