Stereoselective introduction of tetracyclines hydroxyl group at 12(a) position in synthesis of tetracyclines

US3947517A · kind A · utility

Assignee

• AGRESEARCH LIMITED · US

Inventors

• Hans Muxfeldt · Norderstedt, DE
• Jeffrey D. Michael · Milton Keynes, GB

Key dates

• Filing date: Dec 29, 1972
• Grant date: Mar 30, 1976
• Expiry date: Dec 29, 1992

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2603/46
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

In the synthesis of tetracyclines, a critical step is the stereospecific or stereoselective introduction of a hydroxyl group at the C-12(a) position, a novel method for the introduction of this critical hydroxy group is disclosed. Additionally, synthetic procedures for obtaining tetracycline precursors are discussed.