5-Hydroxyl-1,2,3-triazole-4-carboxamide nucleoside
US3948885A · kind A · utility
9Cited by
2References
2Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 19, 1973 |
| Grant date | Apr 6, 1976 |
| Priority date | — |
| Expiry date | Mar 19, 1993 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/056
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A 5-hydroxy-1,2,3-triazole-4-carboxamide nucleoside, related to the C-nucleoside pyrazomycin, is facilely synthesized by condensation of acyl-blocked ribofuranose with trimethylsilylated 5-hydroxy-1,2,3-triazole-4-carboxamide or, alternatively, by cycloaddition of suitably blocked .beta.-D-ribofuranosyl azide and the anion of ethyl malonamate, and demonstrated to exhibit antiviral properties. The triazole precursor of the former route, as well as certain of its novel salts, are also disclosed as potential antiviral agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.