6-Substituted purine 3',5'-cyclic nucleotides
US3948886A · kind A · utility
10Cited by
4References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 8, 1973 |
| Grant date | Apr 6, 1976 |
| Priority date | — |
| Expiry date | Jun 8, 1993 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S526/923
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Described herein are novel 6-alkylthio and 6-arylalkylthio purine 3',5' cyclic nucleotides variously exhibiting adenyl cyclase and (in animal studies) tumor inhibitory properties, interferon potentiation, antiviral activity, and the ability to activate adenosine 3',5'-cyclic phosphate-dependent protein kinase while enjoying resistance to phosphodiesterase hydrolysis superior to that of its naturally occuring analog. The compounds are obtained by alkylation of the corresponding 6-thio nucleotide, which is in turn provided by a novel synthetic route.
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