1,3-Dioxo-2-aminoalkyl-4,4-dimethyl-isoquinolines and salts thereof

US3948898A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Eberhard Kutter
• Volkard Austel
• Wolfgang Eberlein · Biberach, DE
• Joachim Heider · Warthausen, DE

Key dates

• Filing date: Sep 4, 1974
• Grant date: Apr 6, 1976
• Expiry date: Sep 4, 1994

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##SPC1## Wherein R.sub.1 is hydrogen, halogen, methoxy or methylthio PA1 R.sub.2 is hydrogen or methoxy, PA1 n is 2 or 3, and PA1 A is ##SPC2## PA1 Or ##SPC3## PA1 Where R.sub.3 is hydrogen or methyl, PA2 R.sub.4 is pyridyl, methy-pyridyl, phenyl, chlorophenyl, trifluoromethyl-phenyl, tolyl, xylyl, ethyl-phenyl, diethyl-phenyl, methoxy-phenyl or dimethoxy-phenyl, and PA2 R.sub.5 and R.sub.6, which may be identical to or different from each other, are each hydrogen or methoxy, And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as hypotensives, sedatives, antiarrhythmics and bradycardiacs.