3-Substituted-1,2-benzisoxazoles and pharmaceutically acceptable acid addition salts thereof
US3948928A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 12, 1973 |
| Grant date | Apr 6, 1976 |
| Priority date | — |
| Expiry date | Mar 12, 1993 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D261/20
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
3-Substituted-1,2-benzisoxazole derivative of the following formula: ##SPC1## Wherein R.sub.1 is hydrogen, hydroxy, nitro, alkyl, alkoxy, halogen or amino; R.sub.2 is hydroxyamino, amino, hydrazino, mono- or di- alkyl substituted amino, aralkylamino, acyloxyamino, morpholino, piperazine which is unsubstituted or substituted with alkyl, aralkyl or aryl at 4 position, or pyrrolidino, or R.sub.2 may combine with imino group and form together with the adjacent carbon atom a heterocyclic ring such as imidazoline or tetrahydropyrimidine; and n is an integer of 0 to 3, and its pharmaceutically acceptable acid addition salt, and preparation thereof. The present compounds show valuable pharmacological properties, such as anti-reserpine activity, central nervous depressing activity, anti-hypertensive activity and l-dopa potentiating activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.