Amylase inhibitor from wheat gluten using alcohol

US3950319A · kind A · utility

Assignee

• Farbenfabriken Bayer Aktiengesellschaft

Inventors

• Delf Schmidt · Wuppertal, DE
• Walter Puls · Wuppertal, DE

Key dates

• Filing date: Jan 23, 1974
• Grant date: Apr 13, 1976
• Expiry date: Jan 23, 1994

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/415
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An inhibitor for .alpha.-amylases, particularly pancreas amylase, is extracted from wheat, as for example, wheat flour or wheat gluten, by means of aqueous alcoholic solutions of lower alcohols of 1 to 3 carbon atoms, or dilute aqueous acid solutions having a pH of from 1 to 5, or of mixtures of the aqueous alcoholic solutions with dilute acids, and separating the desired amylase inhibitor contained in the aqueous phase from the extraction mixture by known methods. The amylase inhibitor thus obtained is particularly effective against pancreas amylase and is indicated as a therapeutic agent for the treatment of conditions resulting from alimentary hyperglycemia, such as adiposity, arteriosclerosis, diabetes and prediabetes.