Imidazolylacetic acid amides

US3950354A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Jurgen Wenzelburger
• Karl H. Buchel · Burscheid, DE
• Manfred Plempel · Haan, DE
• Werner Meiser

Key dates

• Filing date: Sep 24, 1973
• Grant date: Apr 13, 1976
• Expiry date: Sep 24, 1993

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D249/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Imidazolylacetic acid amides of the formula: ##SPC1## Or pharmaceutically acceptable nontoxic salts thereof wherein PA0 Either PA1 R.sup.1 is phenyl or cycloalkyl, unsubstituted or substituted by one or more substituents; and PA1 R.sup.2 is hydrogen; PA0 Or PA1 R.sup.1 and R.sup.2, together with the nitrogen atom to which they are attached, form a saturated 5 to 7-membered heterocyclic ring which ring may contain an --SO.sub.2 -- or --NY-- moiety wherein Y is alkoxycarbonyl, dialkylaminocarbonyl, or phenyl or diphenylmethyl, unsubstituted or substituted by one or more substituents and wherein said 5 to 7-membered heterocyclic ring itself is otherwise unsubstituted or substituted by one or more substituents; and PA1 X.sup.1, x.sup.2, x.sup.3 and X.sup.4 are the same or different and are each hydrogen or halogen, Are produced by PA0 A. reacting a halodiphenylacetic acid amide of the formula: ##SPC2## PA0 Wherein PA1 R.sup.1, r.sup.2, x.sup.1, x.sup.2, x.sup.3 and X.sup.4 are as above defined, and PA1 Hal is halogen, With imidazole; or PA0 B. reacting a halodiphenylacetic acid halide of the formula: ##SPC3## PA0 Wherein PA1 X.sup.1, x.sup.2, x.sup.3 and X.sup.4 are as above defined an…