Aminobenzyl-amides and salts thereof

US3950393A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Johannes Keck · Zell am Harmersbach, DE
• Klaus Noll · Cologne, DE
• Helmut Pieper · Lohr am Main, DE
• Gerd Kruger
• Sigfrid Puschmann

Key dates

• Filing date: Apr 5, 1974
• Grant date: Apr 13, 1976
• Expiry date: Apr 5, 1994

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D221/24
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##SPC1## Wherein PA1 R.sub.1 is hydrogen or aliphatic or aromatic carboxylic acyl, PA1 R.sub.2 is hydrogen, chlorine or bromine, PA1 R.sub.3 is fluorine, alkyl of 1 to 4 carbon atoms, trifluoromethyl, cyano, carbamoyl, carboxyl, carbalkoxy, alkoxy, acetyl, 1-hydroxyethyl or ##EQU1## where R.sub.6 and R.sub.7 are each alkyl, cycloalkyl, hydroxy-cycloalkyl or, together with each other and the nitrogen atom to which they are attached, pyrrolidino, piperidino or morpholino, and PA1 R.sub.4 and R.sub.5 are each hydrogen, alkyl of 1 to 5 carbon atoms, mono- or di-hydroxy (alkyl of 1 to 5 carbon atoms), alkenyl of 2 to 4 carbon atoms, cycloalkyl of 5 to 7 carbon atoms, mono- or di-hydroxy(cycloalkyl of 5 to 7 carbon atoms), benzyl, morpholinocarbonylmethyl or, together with each other and the nitrogen atom to which they are attached, pyrrolidino, piperidino, hexamethyleneimino, morpholino, N-methyl-piperazino or camphidino, And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as anti-ulcergenics, secretolytics, antitussive, and stimulants of the production of the surfactant or antiatelectasis fact…