1,3-Oxygenated 8.alpha.-estratrienes

US3951959A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Klaus Prezewowsky
• Henry Laurent
• Helmut Hofmeister · Berlin, DE
• Rudolf Wiechert · Berlin, DE
• Friedmund Neumann · Berlin, DE
• Yukishige Nishino · Berlin, DE

Key dates

• Filing date: Jul 12, 1974
• Grant date: Apr 20, 1976
• Expiry date: Jul 12, 1994

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J43/003
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

8.alpha.-Estratrienes of the formula ##SPC1## Wherein R is lower alkyl and X is an oxygen atom, a .beta.-hydroxy or .beta.-hydroxy-.alpha.-substituted or unsubstituted saturated or unsaturated hydrocarbon group, and the esters and ethers thereof, possess strong vaginotropic but only weak utertropic activity and are useful in the treatment of estrogenic deficiency conditions where uteral effects are not desired.