0-(Substituted-aminoalkyl)-5-nitroimidazole-(2)-aldoximes

US3951963A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Erhardt Winkelmann
• Ulrich Gebert · Königstein, DE
• Wolfgang Raether

Key dates

• Filing date: Mar 5, 1974
• Grant date: Apr 20, 1976
• Expiry date: Mar 5, 1994

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D233/95
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel 0-(dialkylaminoalkyl)-1-alkyl-5-nitroimidazole-(2)-aldoximes are described as well as their manufacture and use for treating protozoal diseases. The novel compounds correspond to the general formula ##SPC1## In which R.sup.1 stand for a hydrogen atom, a methyl, ethyl or hydroxyethyl group, Z stands for a linear or branched alkylene chain of 2 to 3 carbon atoms, and R.sup.2 and R.sup.3 each stands for an identical or different lower alkyl radical having from 1 to 4 carbon atoms or the group --NR.sup.2 R.sup.3 can be part of a saturated heterocyclic ring which may contain further substituents preferably a methyl group or/and hetero atoms, such as, especially the pyrrolidine, piperidine, morpholine, thiamorpholine, tetrahydro-1,4-thiazine-1,1-dioxide and piperazine ring, and HX can be a non-toxic, physiologically acceptable acid.