Lactams and process for their manufacture

US3951985A · kind A · utility

Assignee

• Chemie Grunenthal GmbH

Inventors

• Ivars Graudums · Stolberg, DE
• Heinrich Muckter
• Ernst Frankus · Stolberg, DE

Key dates

• Filing date: Feb 27, 1973
• Grant date: Apr 20, 1976
• Expiry date: Feb 27, 1993

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D275/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Lactams of the substituted ortho-sulfobenzoic acid imido pyrrolidone-2, piperidone-2, or caprolactam type. The compounds are useful drugs having therapeutical properties. They are immunosuppressive, sedative, and have antitumor activity. They are produced, for instance, by reacting bromo-lactams with a metal salt of o-sulfobenzoic acid imide.