Anaesthetic composition containing a steroid of the 5.alpha.-pregnane series and method of using same
US3952031A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 13, 1974 |
| Grant date | Apr 20, 1976 |
| Priority date | — |
| Expiry date | Dec 13, 1994 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J7/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to steroids of the pregnane and 19-norpregnane series having anaesthetic properties and compositions containing them. More particularly the present invention relates to such steroids having a variety of substituents in the 2.beta.-position, a 3.alpha.-hydroxy group and a 5.alpha.-hydrogen atom and esters and 20-ketals thereof. At the 11-position of such steroids is preferably either two hydrogen atoms or an oxo group. The compounds according to the invention may conveniently be prepared by reaction of an appropriate 2.alpha.,3.alpha.-epoxy-pregnane or 19-norpregnane with a reagent which introduces the desired 2.beta.-substituent and various modifications of the compound produced are described to produce compounds within the scope of the invention. The present invention provides compositions containing certain steroids of the pregnane and 19-norpregnane series and such compositions generally may be administered intravenously to induce anaesthesia, the invention providing methods of inducing anaesthesia.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.