Synthetic decapeptide having the activity of the luteinizing hormone releasing hormone and method for manufacturing the same

US3953416A · kind A · utility

Inventors

• Karl Folkers · Austin, US
• Bruce L. Currie · Austin, US
• Jaw-Kang Chang · Redwood City, US
• Hans Sievertsson
• Conny B. Bogentoft · Mölndal, SE

Key dates

• Filing date: Jan 14, 1974
• Grant date: Apr 27, 1976
• Expiry date: Jan 14, 1994

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A synthetic decapeptide, L-pglutamyl-L-histidyl-L-tryptophanyl-L-seryl-L-tyrosyl-glycyl-L-leucyl-L- arginyl-L-prolyl-glycinamide which has the hormonal activities of the luteinizing hormone releasing hormone (LRH) of the hypothalamus gland of mammals is produced by utilizing as the key starting materials, the amino acids, glutamic acid or pyroglutamic acid, histidine, tryptophan, serine, tyrosine, glycine, leucine, arginine, and proline. Synthesis of the decapeptide is accomplished by coupling, in appropriate combinations of appropriate protected forms of the amino acids, and finally deprotecting to yield the amide, L-pglutamyl-L-histidyl-L-tryptophanyl-L-seryl-L-tyrosyl-glycyl-L-leucyl-L- arginyl-L-prolyl-glycinamide.