Synthetically modified trypsin inhibitors and process for preparing them

US3953417A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Wolfgang Konig · Hofheim, DE
• Oswald Zwisler
• Gerhard Guthorlein

Key dates

• Filing date: Sep 4, 1974
• Grant date: Apr 27, 1976
• Expiry date: Sep 4, 1994

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Modified trypsin-callicrein inhibitor wherein the five carboxyl groups present in the unmodified material are amidated by EQU --(R)(R).sub.X W groups, Wherein R is prolyl or ##EQU1## X is an integer from 1 to 10, Y is hydrogen, alkyl, or substituted alkyl and W is --OH, --NH.sub.2, --NHC.sub.2 H.sub.5, --OCH.sub.3, or --OC.sub.2 H.sub.5. Method for making trypsin-callicrein inhibitor so modified by amidation.