Patent · US Expired

Derivatives of digoxigenin

US3953431A · kind A · utility

5Cited by

2References

9Claims

0Family size

Assignee

Becton, Dickinson and Company · US

Inventors

Herman Rutner · Hackensack, US
Raul Rapun · Suffern, US
Nathan Lewin · Corte Madera, US

Key dates

Filing date	Sep 28, 1973
Grant date	Apr 27, 1976
Priority date	—
Expiry date	Sep 28, 1993

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10S530/806
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Derivatives of digoxigenin which are either unlabeled or radioiodinated having the following structural formula: ##SPC1## Wherein R' is hydroxyl or acetoxy; B is succinyl, phthaloyl, maleyl or fumaryl, preferably succinyl, and X is hydroxyl or alkali metal salt thereof; a protein conjugate; a peptide conjugate; or an amino acid or amnio acid ester radical. The radiolabeled compounds are used in the radioimmunological assay of digoxin. The preferred compound is radioiodinated 3-succinyl digoxigenin-L-tyrosine.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.