8,12-Dialkyl-PGE, and PGF.sub.1.sub..alpha.
US3953499A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 14, 1974 |
| Grant date | Apr 27, 1976 |
| Priority date | — |
| Expiry date | Jun 14, 1994 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D317/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Prostaglandins E.sub.1 -type and F.sub.1 -type compounds of the formula ##EQU1## wherein R is hydrogen or a hydrocarbyl group containing from 1 to 12 carbon atoms, inclusive, wherein W is ##EQU2## or O =, wherein R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11, R.sub.12, R.sub.13, and R.sub.14 are hydrogen or alkyl of 1 to 4 carbon atoms, inclusive, provided (1) that at least one of R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11, R.sub.12, R.sub.13, and R.sub.14 is alkyl (2) that when R.sub.13 is alkyl, at least one of R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11, R.sub.12, and R.sub.14 is alkyl, and (3) that when R.sub.7 is alkyl or thwn R.sub.7 and R.sub.8 are alkyl, at least one of R.sub.9, R.sub.10, R.sub.11, R.sub.12, R.sub.13, and R.sub.14 is alkyl; and the enantiomers and racemic mixtures thereof. These are useful for the same pharmacological purposes as the unsubstituted prostaglandins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.