Process for fluorinating uracil and derivatives thereof
US3954758A · kind A · utility
10Cited by
2References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 4, 1971 |
| Grant date | May 4, 1976 |
| Priority date | — |
| Expiry date | Oct 4, 1991 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D239/54
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Direct fluorination of uracil and its derivatives, in the presence of an aqueous solvent, by fluorine gas to produce 5-fluorouracil and 5-fluorouracil derivatives is disclosed. Novel compounds produced by the reaction, such as 5,5-difluoro-6-hydroxy-5,6-dihydrouracil are also disclosed. The derivatives of 5-fluorouracil are useful as germicidal agents while 5-fluorouracil itself is a known cancer chemotherapy agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.