Carbazole derivatives

US3956295A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Helmut Biere · Berlin, DE
• Hanns Ahrens
• Clemens Rufer
• Eberhard Schroder
• Henning Koch

Key dates

• Filing date: Jul 17, 1974
• Grant date: May 11, 1976
• Expiry date: Jul 17, 1994

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/405
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Carbazoles of the formula ##SPC1## Wherein R.sub.1 is hydroxymethyl, alkanoyloxymethyl, tetrazolyl, cyano, oximinocarbonyl, aminocarbonyl, carboxyl and salts thereof with physiologically acceptable bases and the esters thereof with physiologically acceptable alcohols and amides thereof with physiologically acceptable amines, PA1 R.sub.2 through R.sub.6 each are a hydrogen atom, halogen atom, lower alkyl, trifluoromethyl, or lower alkoxy, or PA1 R.sub.5 and R.sub.6 collectively are a five- or six-membered isocyclic ring, and PA1 R.sub.7 is a hydrocarbon of 3-8 carbon atoms or, when at least one of the R.sub.2 through R.sub.6 is other than a hydrogen atom, a hydrogen atom, methyl or ethyl, PA1 And the corresponding compounds wherein R.sub.7 is a hydrogen atom, methyl or ethyl, PA1 And the 5,6,7,8-tetrahydrocarbazoles, possess topical anti-inflammatory activity.