1-Substituted-4-benzylpiperidines
US3956296A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 11, 1974 |
| Grant date | May 11, 1976 |
| Priority date | — |
| Expiry date | Dec 11, 1994 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D211/32
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel 1-substituted-4-benzylpiperidines having .alpha.-substituents on the 4-benzyl moiety useful as antiinflammatory agents, sedatives, and tranquilizers are represented by the formula ##SPC1## Wherein R represents acetyl, aryloxyloweralkyl, aroylloweralkylcarbamoyl, N-lower-alkylcarbamoyl, N,N-dilower-alkylcarbamoyl, N-arylcarbamoyl, N-(.omega.-nitrogen containing heterocycle)lower-alkylcarbamoyl, N-(.omega.-aminolower-alkyl)carbamoyl, 2-hydroxy-3-(o-methoxyphenoxy)propyloxycarbamoyl, 2-carbamoylethyl, or 4-(p-fluorobenzoyl)piperidinoethyl; R.sup.1 represents hydrogen or hydroxy; R.sup.2 represents phenyl, p-fluorophenyl, m-trifluoromethylphenyl or cyclohexyl; Y represents hydrogen or fluorine with the proviso that when Y is hydrogen and R.sup.2 is phenyl, R is other than aroylloweralkyl. The pharmaceutically acceptable acid addition salts of the basic compounds of Formula I are included as part of the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.