Novel pregnanoic acid derivatives

US3956347A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Henry Laurent
• Rudolf Wiechert · Berlin, DE
• Klaus Mengel
• Hans Wendt · Berlin, DE

Key dates

• Filing date: Apr 15, 1974
• Grant date: May 11, 1976
• Expiry date: Apr 15, 1994

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J7/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Steroids of the formula ##SPC1## Wherein X is a hydrogen atom, a halogen atom or methyl; Y is a hydrogen atom or a halogen atom; Z is carbonyl, .beta.-acyloxymethylene or, when Y is a hydrogen atom, also methylene; R.sub.1 is a hydrogen atom or methyl; R.sub.2 is a hydrogen atom, an alkali metal atom or optionally substituted hydrocarbon; and --A--B-- is --CH=CH--, --CCl=CH-- or when at least one of X, Y and R.sub.1 is other than a hydrogen atom, --CH.sub.2 --CH.sub.2 --, which can be produced by oxidizing a corresponding 20-hydroxy steroid or a corresponding 21-aldehyde, possess topical anti-inflammatory activity.