Aryl-oxo-heptenoic acids
US3956374A · kind A · utility
40Cited by
1References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 3, 1974 |
| Grant date | May 11, 1976 |
| Priority date | — |
| Expiry date | May 3, 1994 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C59/90
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel 4-phenyl-4-substituted-5-oxo-7-aryl-heptanoic acids are prefaced by either of two synthetic processes. The first method involves the reaction of a 4-phenyl-4-substituted-5-oxo-hexanoic acid with an arylcarboxyaldehyde. The second method involves reaction of an arylcarboxaldehyde with an appropriate ketone, treatment of the product with an acrylic acid ester, followed by hydrolysis of the resulting ester. The compounds of the invention are prostaglandin antagonists and are particularly useful as topical anti-inflammatory agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.