Hydrosoluble extracts of mycobacteria, their preparation and use

US3956481A · kind A · utility

Assignee

• Agence Nationale de Valorisation de la Recherche · FR

Inventors

• Pierre Jolles · Paris, FR
• Daniele Migliore-Samour · Le Kremlin-Bicêtre, FR

Key dates

• Filing date: Jun 19, 1973
• Grant date: May 11, 1976
• Expiry date: Jun 19, 1993

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/55594
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Hydrosoluble extracts of mycobacteria suitable as immunological adjuvants are prepared. These extracts have a molecular weight between 3,500 and 30,000 and adjuvant, non-arthrogen properties. The delipidated bacterial residues of mycobacteria are subjected to a mild extraction, then the so-obtained substance is isolated and purified by physicochemical methods, or the delipidated bacterial residues of mycobacteria are treated by means of pyridine, optionally in the presence of acetic anhydride, then the obtained products are treated with ethanol or water, and the hydrosoluble substances are isolated and purified by physicochemical methods.