1-Substituted-4-(1,2-diphenylethyl)piperazine derivatives and their salts and the preparation thereof
US3957788A · kind A · utility
3Cited by
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23Claims
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Assignee
Inventors
Key dates
| Filing date | Jan 15, 1975 |
| Grant date | May 18, 1976 |
| Priority date | — |
| Expiry date | Jan 15, 1995 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D295/145
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
1-Substituted-4-(1,2-diphenylethyl)piperazine derivatives of the formula: ##SPC1## Wherein X is hydroxy, methoxy, methyl or trifluoromethyl; and R is an unsubstituted monocycloalkyl group having 6 to 8 carbon atoms or 2-methoxyphenyl; provided that when X is hydroxy, R is cyclohexyl, and when X is trifluoromethyl, R is 2-methoxyphenyl, And their pharmaceutically acceptable salts, which have excellent analgesic, anti-tussive and anti-inflammatory activities, without undesirable side effect such as narcotic activity, and a process for the preparation thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.