Antiviral compositions containing bis-basic ketones of xanthene and xanthen-9-one
US3957989A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 20, 1973 |
| Grant date | May 18, 1976 |
| Priority date | — |
| Expiry date | Feb 20, 1993 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel bis-basic ketones of xanthene and xanthen-9-one have antiviral activity when administered orally and parenterally. The compounds are represented by the following formula: ##SPC1## Wherein Z is oxygen or H.sub.2 ; each A is a straight or branched alkylene chain having from 1 to about 6 carbon atoms; and each Y is PA1 A. the group ##EQU1## wherein R.sup.1 and R.sup.2 are individually hydrogen, lower alkyl having from 1 to about 6 carbon atoms, cycloalkyl having from 3 to 6 carbon atoms, alkenyl of from 3 to 6 carbon atoms and having the vinyl unsaturation in other than the 1-position of the alkenyl group; or PA1 B. the group ##EQU2## WHEREIN N IS A WHOLE INTEGER FROM 4 TO 6, AND R.sup.3 is hydrogen, lower alkyl of from 1 to about 4 carbon atoms and can be linked to any one of the carbon atoms of the heterocyclic group; or PA1 C. the group ##EQU3## wherein X is oxygen or NR.sup.4, and R.sup.4 is hydrogen or lower alkyl of from 1 to about 4 carbon atoms; Or a pharmaceutically acceptable acid addition salt thereof. These compounds can be prepared by several different methods.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.