Method of synthesizing 1-(tetrahydro-2-furanyl)-5-fluorouracil
US3960864A · kind A · utility
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8Claims
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Key dates
| Filing date | May 6, 1974 |
| Grant date | Jun 1, 1976 |
| Priority date | — |
| Expiry date | May 6, 1994 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An improved method for synthesizing 1-(tetrahydro - 2-furanyl) - 5-fluorouracil from a silyl derivitive of 5-fluorouracil (bis - trimethylsilyl 5-fluorouracil) by reacting the same with 2-chlorotetrahydrofuran. The reaction is carried out at controlled conditions of temperature and under an inert gas. Yields in excess of 80% of the theoretical are obtained as calculated upon the starting amounts of 5-fluorouracil.
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