1,2-Biguanides

US3960949A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Hanns Ahrens
• Clemens Rufer
• Helmut Biere · Berlin, DE
• Eberhard Schroder
• Wolfgang Losert
• Olaf Loge
• Ekkehard Schillinger · Berlin, DE

Key dates

• Filing date: Jul 9, 1974
• Grant date: Jun 1, 1976
• Expiry date: Jul 9, 1994

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C279/26
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

1,2-Substituted biguanides of the formula ##EQU1## wherein R.sub.1 is saturated or unsaturated, straight-chain or branched hydrocarbon of 1-12 carbon atoms which is unsubstituted or substituted by one or more fluorine atoms; a cycloalkyl group of 3-6 carbon atoms; or an aryl or aralkyl group of the formula ##SPC1## With n being the integer 0, 1 or 2 and X being hydrogen or halogen; and R'.sub.1 is a hydrogen atom or a saturated or unsaturated, straight-chain or branched hydrocarbon group of 1-12 carbon atoms; or R.sub.1 and R'.sub.1 collectively with the nitrogen atom to which they are attached are a heterocyclic ring containing one or more hetero atoms; and R.sub.2 is saturated or unsaturated, straight-chain or branched hydrocarbon of 1-12 carbon atoms which is unsubstituted or substituted by one or more fluorine atoms; or cycloalkyl of 3-6 carbon atoms, alkoxyalkyl containing a total of 2-12 carbon atoms, or alkoxy of 1-6 atoms; mixtures thereof, and pharmaceutically acceptable acid addition salts thereof, are useful in the treatment of diabetes mellitus.