Benzopyrano(3,4-C)pyridine bronchodilators
US3961057A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 3, 1975 |
| Grant date | Jun 1, 1976 |
| Priority date | — |
| Expiry date | Jan 3, 1995 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/535
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Substituted benzopyrano[3,4-c]pyridines having the following structural formula are disclosed: ##SPC1## In the above formula, R.sub.1 and R.sub.2 are hydrogen, a hydroxyl group or a lower alkoxyl group of from 1 to 6 carbon atoms; R.sub.3 is hydrogen or a lower alkyl group of from 1 to 6 carbon atoms and X is an oxygen atom, a sulfur atom, a methylene group or a nitrogen atom substituted by hydrogen, a lower alkyl group of from 1 to 6 carbon atoms or a lower alkanoyl group of from 1 to 6 carbon atoms. The compounds of this invention are prepared by reacting an R.sub.1, R.sub.2 -substituted phenol with a 3-carbethoxy-4-piperidone in the presence of an acid catalyst to give an intermediate R.sub.1, R.sub.2 -substituted benzopyrano[3,4-c]pyridine. N-aminoalkylbenzopyrano[3,4-c]pyridines are obtained by treating the benzopyrano[3,4-c]pyridine with an appropriately substituted alkyl halide. The compounds of this invention are useful as bronchodilators for the treatment of bronchial asthma.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.