Process for preparing amino substituted .beta.-lactam antibiotics
US3962214A · kind A · utility
3Cited by
0References
1Claims
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Key dates
| Filing date | Jul 11, 1974 |
| Grant date | Jun 8, 1976 |
| Priority date | — |
| Expiry date | Jul 11, 1994 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D499/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
6-Acylamino-6-alkylthiopenicillanic or 7-acylamino-7-alkylthiocephalosporanic acids or esters are reacted at a temperature between -80.degree. and -25.degree.C. with one equivalent of halogen to provide an intermediate halosulfonium halide which is reacted with a C.sub.1 -C.sub.4 alkyl amine, a C.sub.1 -C.sub.4 dialkylamine or ammonia in an appropriate solvent. The ester group is removed to provide the 6-aminopenicillanic or 7-aminocephalosporanic acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.