Novel pro-drug derivatives of pyridinium aldoxime type cholinesterase reactivators and method of using same
US3962447A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 11, 1975 |
| Grant date | Jun 8, 1976 |
| Priority date | — |
| Expiry date | Aug 11, 1995 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D211/82
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
There is provided, novel pro-drug forms of pyridinium aldoxime type cholinesterase reactivators, namely, dihydropyridinium aldoximes, having the formula: ##SPC1## Wherein R represents a member selected from the group consisting of an alkyl (C.sub.1 -C.sub.4) group, a ##SPC2## Group, a ##SPC3## Group, ##SPC4## Group, and a ##SPC5## Wherein Z represents a member selected from the group consisting of a --CH.sub.2 --CH.sub.2 -- group, a --CH.sub.2 --O--CH.sub.2 -- group, a --CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 -- group, and a --CH.sub.2 O--CH.sub.2 --CH.sub.2 --O--CH.sub.2 -- group; wherein R.sub.1 represents a member selected from the group consisting of a hydrogen atom, a methyl group, an acyl group and a ##EQU1## group; and wherein X.sup.- represents an anion derived from a pharmaceutically acceptable acid addition salt. These compounds are useful in reactivating cholinesterase, inhibited following exposure to and/or ingestion of conventional anti-cholinesterase agents, especially in the brain.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.