Pharmacologically active pyridine derivatives
US3963729A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 18, 1973 |
| Grant date | Jun 15, 1976 |
| Priority date | — |
| Expiry date | Dec 18, 1993 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D295/185
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
3-Phenyl-3-aminoalkyl-2,6-dioxo-tetra and hexahydropyridines which are substituted in at least one of the 4 and 5 positions of the hydrogenated pyridine ring by a C.sub.1 -C.sub.4 alkyl group or by a divalent radical which together with at least one of the carbon atoms at said 4 and 5 positions forms a carbocyclic ring of 3 to 8 carbon atoms are novel compounds having pharmacological, in particular central nervous system, especially anti-depressant activity. Alkyl esters, dialkylamides and heterocyclic amides of 4-amino-alkyl-4-cyano-4-phenyl-butanoic and but-2-enoic acids substituted in at least one of the 2 and 3 positions by a C.sub.1 -C.sub.4 alkyl group or by a divalent alkylene radical which together with at least one of the carbon atoms at said 2 and 3 positions forms a carbocyclic ring of 3 to 8 carbon atoms are novel intermediates involved in the preparation of the said pharmacologically active compounds. Several methods are disclosed for preparing the pharmacologically active compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.