Process for the preparation of L-car-bamyl-amino acids and of the corresponding L-amino acids

US3964970A · kind A · utility

Assignee

• SNAMPROGETTI S.p.A. · IT

Inventors

• Dino Dinelli · Roma, IT
• Franco Morisi · San Giovanni in Persiceto, IT
• Delio Zaccardelli · Monterotondo, IT

Key dates

• Filing date: May 10, 1974
• Grant date: Jun 22, 1976
• Expiry date: May 10, 1994

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P41/009
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A process for the preparation of only one of the two stereoisomer forms carbamyl amino acids is provided wherein certain heterocyclic compounds having an assymmetrical carbon, such as 5-substituted hydantoins, are hydrolyzed in the presence of certain enzymes, such as dihydropyrimidinase extracted from calf liver. In another embodiment of the invention, the corresponding amino acids are provided by hydrolyzing the carbamyl amino acids in the presence of these same enzymes.