4-Nitroperhydropyrido[1,2-a][1,4]diazepines

US3965103A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Helmut Biere · Berlin, DE
• Hermann Ulbrich
• Hans-Joachim Kessler
• Ulrich Redmann

Key dates

• Filing date: Sep 20, 1974
• Grant date: Jun 22, 1976
• Expiry date: Sep 20, 1994

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula v,2/12 Wherein R.sub.1 is H, lower-alkyl, hydroxyalkyl, phenyl, aralkyl, or --(CH.sub.2) .sub.n --X wherein n is 0-4 and X is --COO-lower-alkyl, C.tbd.N or --COOH and R.sub.2 is H, lower-alkyl or aralkyl, produced by condensing a diamine of the formula ##SPC1## With a nitro compound of the formula R.sub.1 --CH.sub.2 --NO.sub.2 in the presence of formalin or paraformaldehyde, or with the R.sub.1 -- C(CH.sub.2 OH).sub.2 NO.sub.2 reaction product of the above nitro compound and formalin or paraformaldehyde, or with formalin or paraformaldehyde followed by reaction with the above nitro compound, and their acid addition salts, possess antimicrobial activity against both gram-positive and gram-negative bacteria and also against dermatophytes, yeasts and other fungi.