7-.beta.-Acylamido-3-carbamoyloxymethylceph-3-em-4-carboxylic acids and salts thereof
US3966717A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 8, 1973 |
| Grant date | Jun 29, 1976 |
| Priority date | — |
| Expiry date | Nov 8, 1993 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D501/26
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention provides novel antibiotic compounds comprising 7.beta.-acylamido-3-carbamoyloxymethylceph-3-em-4-carboxylic acids and non-toxic derivatives thereof wherein the acylamido group has the structure ##EQU1## IN WHICH R is a carbocyclic or heterocyclic aryl group and R.sup.a is a lower alkyl, cycloalkyl or phenyl group. The compounds are syn isomers or exist as mixtures containing at least 75% of the syn isomer. These antibiotic compounds possess high antibacterial activity against a range of gram positive and gram negative organisms coupled with particularly high stability to .beta.-lactamases produced by various organisms and stability in the presence of human serum. The invention is also concerned with the administration of the compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.