8-Substituted cyclic nucleotides by free radical alkylation and acylation
US3968101A · kind A · utility
6Cited by
0References
17Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 20, 1974 |
| Grant date | Jul 6, 1976 |
| Priority date | — |
| Expiry date | Dec 20, 1994 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel compounds of the general formula ##SPC1## Wherein X is H or NH.sub.2 ; R' is C.sub.1 to C.sub.8 alkyl, C.sub.1 to C.sub.8 substituted alkyl, benzyl, C.sub.1 to C.sub.8 acyl, benzoyl, carbamoyl, are disclosed as well as a novel free radial alkylation and acylation process for making such compounds. The compounds of the invention display activity comparable to or superior to their naturally occurring analogue while resisting phosphodiesterase degradation. In some cases the compounds of this invention actually inhibit enzymatic degradation of the natural analogue.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.