Production of 2-(thio substituted)cephalosporin sulfoxides and 2-(thio substituted)cephalosporins
US3968109A · kind A · utility
3Cited by
2References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 23, 1973 |
| Grant date | Jul 6, 1976 |
| Priority date | — |
| Expiry date | Nov 23, 1993 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D501/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A new method of producing 2-(thio substituted) cephalosporin derivatives comprises treating a cephem sulfoxide with an electrophilic sulfur reagent in the presence of a strong base. The cephem sulfoxides produced by this step are useful as intermediates, which by reduction of the sulfoxide group, yield 2-(thio substituted) cephalosporins having useful antimicrobial activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.