Process for the conversion of niddamycin to leucomycin A.sub.1, leucomycin A.sub.3, carbomycin B and other antibiotics and related 3-O-esters
US3970642A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jun 3, 1974 |
| Grant date | Jul 20, 1976 |
| Priority date | — |
| Expiry date | Jun 3, 1994 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H17/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Covers the process for the conversion of niddamycin to known compounds such as carbomycin B, leucomycin A.sub.1 and A.sub.3, and other antibiotic compounds as well as novel 3-(O)-esters 3-(0)-esters and dimethyl acetal derivatives not obtained from natural sources. These compounds are represented by the general formula: ##SPC1## Wherein R is hydroxy or oxygen, R.sub.1 is hydrogen, HCO (formyl), CH.sub.3 CO (acetyl), CH.sub.3 CH.sub.2 CO (propionyl) or CH.sub.3 CH.sub.2 CH.sub.2 CO (butyryl); wherein R.sub.2 is hydrogen or equivalent to R.sub.1 and R.sub.3 is CHO or CH(OCH.sub.3).sub.2. These compounds are useful antimicrobial agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.