Cephalosporins having (.alpha.-etherified oximino)acylamido groups at the 7-position
US3971778A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 7, 1972 |
| Grant date | Jul 27, 1976 |
| Priority date | — |
| Expiry date | Nov 7, 1992 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/60
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention provides novel antibiotic compounds which are 7.beta.-acylamidoceph-3-em-4-carboxylic acids, and non-toxic derivatives thereof characterized in that the acylamido group has the structure ##EQU1## where R is a hydrogen atom or an organic group and R.sup.a is an etherifying monovalent organic group linked to the oxygen atom through a carbon atom. The compounds are syn isomers or exist as mixtures containing at least 75% of the syn isomer. These antibiotic compounds possess high antibacterial activity against a range or gram positive and gram negative organisms coupled with particularly high stability to .beta.-lactamases produced by various gram negative organisms. The invention is also concerned with the administration of the compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.