Synthesis of racemic 2-deutero-3-fluoro-alanine and its salts
US3972921A · kind A · utility
4Cited by
2References
7Claims
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Key dates
| Filing date | Nov 8, 1974 |
| Grant date | Aug 3, 1976 |
| Priority date | — |
| Expiry date | Nov 8, 1994 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/05
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The racemates of 2-deutero-3-fluoro-alanine and its salts are prepared by reductive amination of 3-fluoro-pyruvic acid, its hydrate or salts thereof, via the intermediate 2-imino-3-fluoro propionic acid salt, using alkali metal borodeuterides as reducing agents. The racemates thus obtained are valuable in the production of the corresponding 2-deutero-3-fluoro-D-alanine, and its pharmacologically acceptable salts, and derivatives thereof, which are potent antibacterial agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.