Modification of polystyrene by Friedel-Crafts reaction with substituted halo ethyl benzenes and haloethylphenols to make supports for solid phase peptide synthesis
US3974110A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 3, 1974 |
| Grant date | Aug 10, 1976 |
| Priority date | — |
| Expiry date | Oct 3, 1994 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08F8/10
- WIPO fieldMacromolecular chemistry, polymers
- WIPO sectorChemistry
Abstract
A process for producing reagents useful in organic synthesis, of the general formula ##SPC1## Wherein PA1 Z designates the ##EQU1## part of a polymeric backbone of a polymer like polystyrene, a copolymer comprising polystyrene and a comonomer like divinylbenzene, butadiene, and other copolymers comprising styrene, or wherein Z designates the aliphatic moiety of a long-chain aralkyl compound having a terminal phenyl moiety; PA1 n is an integer from 1 to 8, inclusive; PA1 R designates oxygen or sulfur; PA1 X designates nitro, carbonyl, carboxyl, cyano-carbalkoxy or a carboxamido group which may be substituted on the nitrogen atom, or a halogen atom, or alkyl, unsaturated alkyl, aralkyl; RH and X together designate hydroxytriazole; which comprises reacting a compound of the general formula ##SPC2## Wherein Y designates --Cl, --Br, or --OH and X and R are as defined above, with a polystyrene polymer or with a copolymer as defined above, or with a long-chain araliphatic compound as defined above, in a Friedel-Crafts reaction. According to a preferred embodiment copolymers of polystyrene and divinylbenzene are used. The invention also relates to the novel products obtained by the above r…
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