Arabinofuranosyl N.sup.4 -aminoacyl cytosine containing compounds
US3975367A · kind A · utility
21Cited by
4References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 30, 1974 |
| Grant date | Aug 17, 1976 |
| Priority date | — |
| Expiry date | Aug 30, 1994 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Certain new 1-(3',5'-O-Variable-.beta.-D-arabinofuranosyl)-N.sup.4 -.alpha.-aminoacylcytosines, for example, 1-(5'-O-palmitoyl-.beta.-D-arabinofuranosyl)-N.sup.4 -[N.sup..alpha.-[N-(tert-butoxycarbonyl)glycyl]-L-arginyl]cytosine hydrochloride, have been found active against neoplastic cells, viruses, and as immunosuppressants. The 3'-O-, or 5'-O-, variability includes the hydrogen atom and acyl groups. The N.sup.4 -.alpha.-aminoacyl group comprises .alpha.-amino acids, N-protected .alpha.-amino acids, and similar peptidyl sequences of .alpha.-amino acids. Acid addition salts are an embodiment of the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.