Preparing carboxylic acids from glycidonitriles through enol acylates
US3975431A · kind A · utility
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Key dates
| Filing date | Dec 10, 1974 |
| Grant date | Aug 17, 1976 |
| Priority date | — |
| Expiry date | Dec 10, 1994 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D303/48
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Process for preparing carboxylic acids by converting a glycidonitrile to the enol acylate via hydrohalogenation, acylation and dehydrohalogenation procedures, and conversion of the enol acylate to the carboxylate salt with a base and of the salt to the carboxylic acid with acid. Cyanide content in the mixture is destroyed by adding persulfate or hypochlorite salts. This process, can be used, e.g., to prepare 2-(4'-isobutylphenyl)propionic acid, now known generically as ibuprofen, a highly active anti-inflammatory drug, as well as a host of other useful carboxylic acids.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.