13-Norleucine-14-desamido motilin, a method for preparing it and an agent containing it

US3978035A · kind A · utility

Assignee

• Max-Planck-Gesellschaft zur Föderung der Wissenschaften e.V. · US

Inventors

• Erich Wunsch · Tutzing, DE
• Gerhard Wendlberger
• Ernst Jaeger
• Regine Scharf
• Karl-Heinz Deimer
• Hans Peter STOCKER

Key dates

• Filing date: Mar 27, 1974
• Grant date: Aug 31, 1976
• Expiry date: Mar 27, 1994

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The specification describes the total synthesis of L-norleucine-13-motilin ased on the replacement of the L-methionine radical located in the 13-position by an L-norleucine radical. In accordance with the present day development of peptide synthesis the central arginyl-methionyl-bond (amino acids 12 and 13 of motilin) can in practice hardly be synthesised, while on the other hand the norleucine-13-docosapeptide corresponding to motilin can be more readily produced synthetically, and this provides for a comparatively rapid determination of structure and can give important information as regards the biological effect specificity of methionine.